An all-day trip from New Orleans that can be spread over 2 days if you want to take your time exploring the sights.
I tried to stay off major highways as much as possible whenever there was a sensible alternative.
I headed straight out to Grand Isle and then touched some towns on the way back: Houma, Morgan City and Thibodaux.
Grand Isle is very picturesque and the State Park there has a nice beach (gulf water but still nice and somewhat refreshing for a quick swim) and facilities if you want to stay overnight and camp. Houma is not a very pretty town, but has a good food place worth stopping at if you are hungry (see below).
Morgan City has a great old rusty iron bridge worth riding through, and some docks to look at, apparently there are good food options here too but I did not investigate.
Thibodaux has a really nice historical downtown district, worth taking a look at.
Lots of tasty food to be had throughout the route, but I can recommend Joe Bob for a quick bite in Grand Isle, The Shack in Houma or one of the few places in the Thibodaux historical downtown area.
Enjoy and ride safe!
This is a nice daytrip out from New Orleans to the end of the Mississippi river, with virtually no highway/motorway use.
The road gets progressively more scenic as you leave the city, going through a lot of rural / swampland and bayou landscape.
Once you get to the end (past Port Sulphur) it gets even more scenic with some really interesting points where the road is really close to the water.
Nice food stop at LA 23 BBQ, either on your way out or back depending on your timing (it is only 30 mins out from the city).